Stopping treatment with cyclic antidepressants

Cyclic antidepressants aren't considered addictive. However, stopping antidepressant treatment abruptly or missing several doses can cause withdrawal-like symptoms. Symptoms may vary depending on how the drug works. This is sometimes called discontinuation syndrome. Work with your doctor to gradually and safely decrease your dose.

Withdrawal-like symptoms can include:

• Agitation, irritability or anxiety
• Nausea
• Sweating
• Flu-like symptoms, such as chills and muscle aches
• Insomnia
• Lethargy
• Headache